Efficacy and Safety of Intravitreal Triamcinolone Injection in the Treatment of Cystoid Macular Edema
DOI:
https://doi.org/10.65693/j21umas.2024.v3i1.201Keywords:
Macular Edema, Steroids, TriamcinoloneAbstract
Cystoid Macular Edema (CME) is a major concern for global vision health, often resulting in
distorted vision due to fluid accumulation in the macula. Intravitreal Triamcinolone (IVT)
injections have emerged as a promising treatment, reducing macular thickening and improving
visual acuity. This study aimed to assess the efficacy and safety of IVT injections in treating
CME triggered by various diseases and improving visual acuity. The study included 20 eyes of
12 patients with CME associated with conditions such as diabetic mellitus type II, pseudophakia,
central retinal vein occlusion (CRVO), Aphakia, retinitis pigmentosa, and panuveitis. A reduced
dose of IVT was administered to mitigate corticosteroid-related complications. Each patient
received a single IVT injection of triamcinolone acetate. The initial findings indicated the
efficacy of IVT injections in managing CME, particularly in cases related to diabetic retinopathy,
uveitis, and central retinal vein occlusion. The study provided valuable insights into the efficacy
of IVT injections in managing CME across diverse disease conditions, with observed
improvements in visual acuity and resolution of CME.
References
Yanyali A, Nohutcu AF, Horozoglu F, Celik E. Modified grid laser photocoagulation versus pars plana vitrectomy with internal limiting membrane removal in diabetic macular edema. American journal of ophthalmology. 2005;139(5):795-801. Holló G, Aung T, Cantor LB, Aihara M. Cystoid macular edema related to cataract surgery and topical prostaglandin analogs: Mechanism, diagnosis, and management. Survey of Ophthalmology. 2020;65(5):496-512. Antonetti DA, Klein R, Gardner TW. Diabetic retinopathy. The New England journal of medicine. 2012;366(13):1227-39. Jonas JB, Kreissig I, Degenring R. Intravitreal triamcinolone acetonide for treatment of intraocular proliferative, exudative, and neovascular diseases. Progress in Retinal and Eye Research. 2005;24(5):587-611. Munk MR, Somfai GM, de Smet MD, Donati G, Menke MN, Garweg JG, et al. The Role of Intravitreal Corticosteroids in the Treatment of DME: Predictive OCT Biomarkers. International journal of molecular sciences. 2022;23(14). Tariq F, Wang Y, Ma B, He Y, Zhang S, Bai L. Efficacy of Intravitreal Injection of Filtered Modified Low-Dose Triamcinolone Acetonide and Ranibizumab on Pseudophakic Cystoid Macular Edema. 2022:9. Becerra EM, Morescalchi F, Gandolfo F, Danzi P, Nascimbeni G, Arcidiacono B, et al. Clinical evidence of intravitreal triamcinolone acetonide in the management of age-related macular degeneration. Current drug targets. 2011;12(2):149-72. Moon J, Kim M, Sagong M. Combination therapy of intravitreal bevacizumab with single simultaneous posterior subtenon triamcinolone acetonide for macular edema due to branch retinal vein occlusion. Eye. 2016;30(8):1084-90. Tao Y, Jonas JB. Intravitreal triamcinolone. Journal d'ophtalmologie: Ophthalmologica: International journal of ophthalmology: Zeitschrift fur Augenheilkunde. 2011;225(1):1-20. Beck RW, Moke PS, Turpin AH, Ferris FL, 3rd, SanGiovanni JP, Johnson CA, et al. A computerized method of visual acuity testing: adaptation of the early treatment of diabetic retinopathy study testing protocol. American journal of ophthalmology. 2003;135(2):194-205. Dang Y, Mu Y, Li L, Mu Y, Liu S, Zhang C, et al. Comparison of dexamethasone intravitreal implant and intravitreal triamcinolone acetonide for the treatment of pseudophakic cystoid macular edema in diabetic patients. Drug design, development and therapy. 2014;8:1441-9. Scott IU, Ip MS, VanVeldhuisen PC, Oden NL, Blodi BA, Fisher M, et al. A randomized trial comparing the efficacy and safety of intravitreal triamcinolone with standard care to treat vision loss associated with macular Edema secondary to branch retinal vein occlusion: the Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) study report 6. 2009;127(9):1115. Young S, Larkin G, Branley M, Lightman S. Safety and efficacy of intravitreal triamcinolone for cystoid macular oedema in uveitis. Clinical & experimental ophthalmology. 2001;29(1):2-6.
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Copyright (c) 2024 Nabil Taresh، Talal Haider، Basma Al-Refai (المؤلف)

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