Health Related Quality of life among patients with Chronic Liver Diseases at Public Hospitals in Sana'a City 2022
DOI:
https://doi.org/10.65693/irss.2024.v5i1.160Keywords:
Chronic Liver Disease (CLD), Health-Related Quality of Life (HRQOL), EQ-5D-5L, Liver Disease Symptom Index (LDSI), Child-Pugh Score, MELD Score, Public Hospitals, Sana'a, YemenAbstract
Background: Chronic liver disease is a leading cause of mortality and morbidity across the world. It is the 11th leading cause of death and 15th leading cause of morbidity. Health related quality of life is a multidimensional construct that includes the psychological, social, and functional aspects of an illness as well as its physical aspects.
Aim of the study: The aim of the study was to evaluate health related quality of life among patients with chronic liver diseases at public hospitals in Sana'a city.
Methodology: A hospital-based, descriptive cross-sectional study was used. The sample size was 197 patients. The sample was approached at the public hospitals in the medical wards and out-patients departments. The data collection tools consisted of two parts: the healthy related quality of life questionnaires and the clinical data sheet. The data was analyzed by the SPSS program.
Results: The mean age of the patients was more than 55 years, 75.9% of them are males, and 45.4% of them are free workers. 91.4% of the patients complain of fatigue, and 73.0% have right hypochondrium pain and ascites. Positive autoantibody represents 41.3% of the causes of CLD. About 48.3% of the patients are in class B followed by class C according to the Child-Pugh Score, and the mean $\pm$ SD score of the MELD score is $16.3 \pm 11.27$ for the disease severity.
Furthermore, 41.4% of patients have slight problems in mobility and 43.7% in usual activity. Half of them have problems in self-care, and approximately one-third of them have slight problems associated with pain and discomfort, while one-third have no problem with anxiety or depression. The majority of patients suffer from jaundice and loss of appetite.
Conclusion: The overall LDSI is low in the hindrance of the patient regarding daily activities and social life. There are statistically significant differences among patients' EQ-5D-5L scores regarding age, level of education, occupation, monthly income, and yearly income. There are also statistically significant differences among patients' Child-Pugh scores regarding the liver disease symptom index LDSI, while there are no statistically significant differences among patients' Child-Pugh scores regarding the EQ-5D-5L scores
References
• Abuarij, M., & Al Qtwani, A. (2023). Efficacy of Oral Isotretinoin in Combination with Desloratadine in the Treatment of Acne Vulgaris at Al-Thawrah General Hospital, Sana’a, Yemen . Journal of 21 September University for Medical and Applied Sciences, 2(1), 17-30. https://doi.org/10.65693/masj.2023.v2i1.23
• Al-Akwa, S., Al-Ataki, A., Al-Awadhi, A., Abdulmoghani, I., Al-Madoumi, I., Al-Wesabi, M., Al-Samei, A., Al-Hajjaji, B., Al-Doais, T., Salem, R., Jarwash, F., Al-Nofeesh, M., Al-Azizi, J., & Al-Nazari, M. (2024). The Role of Governance in Improving the Quality of Healthcare Services in Yemeni Hospitals: (A Case Study of the Republican Teaching Hospital Authority). Institutional Repository for Scientific Scholarship at 21 September University for Medical and Applied Sciences, 5(1), 1-133. https://doi.org/10.65693/irss.2024.v5i1.39
• Al-Wesabi, M. (2020). The reality of the Yemeni health sector and the role of September 21 University for Medical and Applied Sciences in reforming it and building the modern Yemeni state (M. Dael, Trans.). Institutional Repository for Scientific Scholarship at 21 September University for Medical and Applied Sciences, 1(1), 106-133. https://doi.org/10.65693/irss.2020.v1i1.47
• Al-Wesabi, M., & Jarallah. et al, M. (2024). The Reality of Training Quality and its Role in Improving the Performance of Operating Theater Technicians in Yemeni Hospitals: A Comparative Analytical Study Between the Republican Teaching Hospital Authority and Kuwait University Hospital. Institutional Repository for Scientific Scholarship at 21 September University for Medical and Applied Sciences, 5(1), 1-92. https://doi.org/10.65693/irss.2024.v5i1.49
• Al-Wesabi, M., & Shamlan, M. (2022). The Effect of Applying Infection Prevention and Control Standards in Sana’a Governorate Hospitals at the Level of Reducing the Spread of Diseases and Epidemics. Journal of 21 September University for Medical and Applied Sciences, 1(1). https://doi.org/10.65693/masj.2022.v1i1.17
• Alyahawi A, Measar M, Alwesabi M, Alkaf A. (2024). Clinically Significant Statin-Drug Interactions in Older Patients with Chronic Diseases. Pharmaceutical Research - Recent Advances and Trends Vol. 4, B P International, pp.1-21. https://doi.org/10.9734/bpi/prrat/v4/598
• Measar, M., & Al-Hoothi, E. (2023). Giant Cerebral Cavernoma: A Case Study. Journal of 21 September University for Medical and Applied Sciences, 2(1). https://doi.org/10.65693/masj.2023.v2i1.21
• • Akel, K. B., Masters, N. B., Shih, S.-F., Lu, Y., & Wagner, A. L. (2021). Modification of a vaccine hesitancy scale for use in adult vaccinations in the United States and China. Human vaccines & immunotherapeutics, 17(8), 2639-2646.
• • Armengol, C., Bartoli, R., Sanjurjo, L., Serra, I., Amezaga, N., Sala, M., & Sarrias, M.-R. (2013). Role of scavenger receptors in the pathophysiology of chronic liver diseases. Critical Reviews™ in Immunology, 33(1).
• • Arshad, M., Asif, H., John, A., & Pasha, M. O. (2020). Chronic liver disease and it's complications. MARKHOR (The Journal of Zoology), 3-7.
• • Ballinger, A. (2011). Essentials of Kumar and Clark's Clinical Medicine E-Book: Elsevier Health Sciences.
• • Banait, S., Jin, X., Campos, M., & Pérez-Prado, M. (2021). Precipitation-induced transition in the mechanical behavior of 3D printed Inconel 718 bcc lattices. Scripta Materialia, 203, 114075.
• • Bouglouga, O., Lawson-Ananissoh, L., Bagny, A., Kaaga, L., & Amegbor, K. (2015). Stomach cancer: Epidemiological, clinical and histological aspects at the Lome Campus teaching hospital (Togo). Medecine et Sante Tropicales, 25(1), 65-68.
• • Cheemerla, S., & Balakrishnan, M. (2021). Global epidemiology of chronic liver disease. Clinical liver disease, 17(5), 365.
• • Cohen, J. C., Horton, J. D., & Hobbs, H. H. (2011). Human fatty liver disease: old questions and new insights. Science, 332(6037), 1519-1523.
• • da Silva, S., Braido, N., Ottaviani, A., Gesualdo, G., & Zazzetta, M. SEBAGAI FAKTOR RESIKO PENYAKIT GAGAL GINJAL KRONIS. KOSALA: Jurnal Ilmu Kesehatan, 5:. Eunethta, 2013. Health-Related Quality of Lide and Utility Measures. European Network for Health Technology Assessment. Fassbinder, TRC, Winkelmann, ER, Schneider, J., Wendland, J., dan Oliveira. Policy, 4, 174-184.
• • Davidson, D. (2006). The Essential Davidson: OUP Oxford.
• • de Araujo Silva, R., Ruela, A. L. M., de Oliveira Mamede, M. E., & de Paula Pereira, N. (2023). Preparation and sensory evaluation of gels based on silicone copolymers/acrylic copolymers incorporating different vegetable oils. Industrial Crops and Products, 193, 116147.
• • De Souza, R. J., Mente, A., Maroleanu, A., Cozma, A. I., Ha, V., Kishibe, T., . . . Beyene, J. (2015). Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: systematic review and meta-analysis of observational studies. Bmj, 351.
• • Gazineo, D., Godino, L., Decaro, R., Calogero, P., Pinto, D., Chiari, P., . . . Ambrosi, E. (2021). Assisted Walking Program on Walking Ability in In Hospital Geriatric Patients: A Randomized Trial. Journal of the American Geriatrics Society, 69(3), 637-643.
• • Gibbs, H. K., Rausch, L., Munger, J., Schelly, I., Morton, D. C., Noojipady, P., . . . Walker, N. F. (2015). Brazil's soy moratorium. Science, 347(6220), 377-378.
• • Gomes, P., Lima, L. H., Bueno, M. K., Araújo, L. A., & Souza, N. M. (2015). Autism in Brazil: a systematic review of family challenges and coping strategies. Jornal de pediatria, 91, 111-121.
• • Gutteling, B. M., de Weerth, C., Zandbelt, N., Mulder, E. J., Visser, G. H., & Buitelaar, J. K. (2006). Does maternal prenatal stress adversely affect the child‘s learning and memory at age six? Journal of abnormal child psychology, 34, 787-796.
• • Haq, B. U., Ahmed, R., Shaari, A., Hassan, F. E. H., Kanoun, M. B., & Goumri-Said, S. (2014). Study of wurtzite and zincblende GaN/InN based solar cells alloys: First-principles investigation within the improved modified Becke–Johnson potential. Solar Energy, 107, 543-552.
• • Harjola, V. P., Lassus, J., Sionis, A., Køber, L., Tarvasmäki, T., Spinar, J., . . . Carubelli, V. (2015). Clinical picture and risk prediction of short term mortality in cardiogenic shock. European journal of heart failure, 17(5), 501-509.
• • Heidelbauch, J., & Bruderly, M. (2006). Cirrhosis and chronic liver failure: Part I Diagnosis and evaluation.
• • Jameson, J., Fauci, A., Kasper, D., Hauser, S., Longo, D., & Loscalzo, J. (2020). Leukocytosis and leukopenia. Harrison's Manual of Medicine, 20e. In: McGraw-Hill Education: New York. 136.
• • Kalliampakou, K. I., Kalamvoki, M., & Mavromara, P. (2005). Hepatitis C virus (HCV) NS5A protein downregulates HCV IRES-dependent translation. Journal of general virology, 86(4), 1015-1025.
• • Kasper, D., Fauci, A., Hauser, S., Longo, D., Jameson, J., & Loscalzo, J. (2015). Harrison's principles of internal medicine, 19e (Vol. 1): Mcgraw-hill New York, NY, USA.
• • Kudo, M., Izumi, N., Kokudo, N., Matsui, O., Sakamoto, M., Nakashima, O., . . . Hepatology, H. E. P. o. J. S. o. (2011). Management of hepatocellular carcinoma in Japan: Consensus-Based Clinical Practice Guidelines proposed by the Japan Society of Hepatology (JSH) 2010 updated version. Digestive diseases, 29(3), 339-364.
• • Li, H., Li, Q., Wen, P., Williams, T. B., Adhikari, S., Dun, C., . . . Carroll, D. L. (2018). Colloidal cobalt phosphide nanocrystals as trifunctional electrocatalysts for overall water splitting powered by a zinc–air battery. Advanced Materials, 30(9), 1705796.
• • Liu, X., Herzschuh, U., Shen, J., Jiang, Q., & Xiao, X. (2008). Holocene environmental and climatic changes inferred from Wulungu Lake in northern Xinjiang, China. Quaternary Research, 70(3), 412-425.
• • Marrero, J. A., Kulik, L. M., Sirlin, C. B., Zhu, A. X., Finn, R. S., Abecassis, M. M., . . . Heimbach, J. K. (2018). Diagnosis, Staging, and Management of Hepatocellular Carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases. Hepatology, 68(2), 723-750.
• • Marsano, L. S., Vatsalya, V., Hassan, A., & McClain, C. J. (2016). Clinical features, disease modifiers, and natural history of alcoholic liver disease. Alcoholic and non-alcoholic fatty liver disease: bench to bedside, 165-182.
• • Mathai, S. V., Sohal, S., Flatow, E., Nagaraj, S., Hajra, A., Chugh, Y., . . . Cohen, M. (2022). Sex differences in periprocedural and long-term outcomes following transcatheter left atrial appendage occlusion: A systematic review and meta-analysis. Cardiovascular Revascularization Medicine.
• • Mendez-Sanchez, N. Importance of Iron and Iron Metabolism in Nonalcoholic Fatty Liver.
• • Mendez-Sanchez, N., Arrese, M., Gadano, A., Oliveira, C. P., Fassio, E., Arab, J. P., . . . Ridruejo, E. (2021). The Latin American Association for the Study of the Liver (ALEH) position statement on the redefinition of fatty liver disease. The Lancet Gastroenterology & Hepatology, 6(1), 65-72.
• • Moon, A. M., Singal, A. G., & Tapper, E. B. (2020). Contemporary epidemiology of chronic liver disease and cirrhosis. Clinical Gastroenterology and Hepatology, 18(12), 2650-2666.
• • Orr, J. G., Homer, T., Ternent, L., Newton, J., McNeil, M. H., Jones, D. E., & Jones, D. E. (2014). Health Related Quality of Life in People with Advanced Chronic Liver.
• • Penman, I. D., Ralston, S. H., Strachan, M. W., & Hobson, R. (2022). Davidson's Principles and Practice of Medicine E-Book: Elsevier Health Sciences.
• • Pinzani, M., Rombouts, K., & Colagrande, S. (2005). Fibrosis in chronic liver diseases: diagnosis and management. Journal of hepatology, 42(1), S22-S36.
• • Pradhan, R. R., & Sigdel, M. R. (2020). Prevalence, clinical presentation, and outcome of tuberculosis in patients with chronic kidney disease at a tertiary care hospital in Nepal. International journal of nephrology, 2020.
• • Ralston, S. H., Penman, I. D., Strachan, M. W., & Hobson, R. (2018). Davidson's Principles and Practice of Medicine E-Book: Elsevier Health Sciences.
• • Riley, T. R., & Smith, J. P. (1999). Preventive care in chronic liver disease. Journal of general internal medicine, 14(11), 699-704.
• • Riley, T., & Bhatti, A. M. (2001). Preventive strategies in chronic liver disease: part II. Cirrhosis. American family physician, 64(10), 1735.
• • Robinson, S. (2023). Principles and Practice of Health Promotion and Public Health: Routledge 4 Park Square, Milton Park, Abingdon, Oxon OX14 4RN.
• • Schulz, K.-H., Kroencke, S., Ewers, H., Schulz, H., & Younossi, Z. M. (2008). The factorial structure of the chronic liver disease questionnaire (CLDQ). Quality of Life Research, 17, 575-584.
• • Sepanlou, S. G., Safiri, S., Bisignano, C., Ikuta, K. S., Merat, S., Saberifiroozi, M., . . . Abdoli, A. (2020). The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet Gastroenterology & Hepatology, 5(3), 245-266.
• • Sharma, A., & Nagalli, S. (2021). Chronic liver disease. In StatPearls [Internet]: StatPearls Publishing.
• • Silva, A. S. d., Santos, L. L. d., Passos, A. D. C., Sankarankutty, A. K., Martinelli, A. d. L. C., & Castro e Silva, O. d. (2006). Chronic liver disease prevention strategies and liver transplantation. Acta Cirúrgica Brasileira, 21, 79-84.
• • Smith, B., Fricker, H. A., Gardner, A. S., Medley, B., Nilsson, J., Paolo, F. S., . . . Csatho, B. (2020). Pervasive ice sheet mass loss reflects competing ocean and atmosphere processes. Science, 368(6496), 1239-1242.
• • Stern, H. L., Gu, Q., Jarman, J., Eizagirre Barker, S., Mendelson, N., Chugh, D., . . . Aharonovich, I. (2022). Room-temperature optically detected magnetic resonance of single defects in hexagonal boron nitride. Nature communications, 13(1), 618.
• • Terrault, N. A., Lok, A. S., McMahon, B. J., Chang, K. M., Hwang, J. P., Jonas, M. M., . . . Wong, J. B. (2018). Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance. Hepatology, 67(4), 1560-1599.
• • Tsouka, A., & McLin, V. A. (2012). Complications of chronic liver disease. Clinics and research in hepatology and gastroenterology, 36(3), 262-267.
• • Wilkinson, I., Wilkinson, I. B., Raine, T., Wiles, K., Goodhart, A., Hall, C., & O'Neill, H. (2017). Oxford handbook of clinical medicine: Oxford university press.
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