A Study of The Prevalence of Skin Manifestation Among Diabetic Patients Attending Dermatological Outpatient Clinics of Public Hospitals, Sana’a City-Yemen-2023.
DOI:
https://doi.org/10.65693/irss.2024.v5i1.374الكلمات المفتاحية:
Diabetes mellitus, Skin manifestation, Prevalence, dermatology, Yemenالملخص
Background: Skin is the largest organ in the body, and effected by many systemic diseases including diabetes mellitus. Diabetes mellitus effected the skin by different mechanism, that lead to varies manifestations and skin problems, some of them appear on asymptomatic patient
and can be the first indictor for the presence of diabetes mellitus and usually go undiagnosed , while others related to the control of diabetes and lead to serious complication which needs control of blood sugar to be treated.
Objective: The study was conducted to determine the prevalence of different skin manifestation on diabetic patients and enhance knowledge regarding their definition, diagnosis, prevention and treatment methods of them.
Methodology: study is a descriptive cross-sectional study conducted on three of public civilian hospital in Sana'a city, Yemen. A structured Arabic questionnaire was implemented using face-to-face interviews. Statistical analysis had be performed using the SPSS software.
Results: The sample size was eighty-seven 87 participants, among the participants type 1 diabetes mellitus was present in 20 (23%) of participants, while type 2 diabetes mellitus present in 67(77%) of them. Manifestations of skin infection was present as follow fungal infections in 43 (49.4%), bacterial infections in 32(36.8%) and viral infections in 31(35.6%). In non-infectious manifestations dry skin was the commonest detected in 50(57.5%) of patients followed by pruritus 36(41.4 %), acrochordons 26(29.9%), acanthosis nigricans 19(21.8%), Vitiligo 16(18.4%), Necrobiosis lipoidica 13(14%) and Bullosis Diabeticorum 3(3.5%).
Conclusion: Patients with diabetes mellitus either type 1 diabetes mellitus or type 2 diabetes mellitus may be had one or more skin manifestation, which more common in type 2 diabetes mellitus.
المراجع
Abdelghany, M., & Massoud, S. (2015). Eruptive xanthoma. Hemoglobin, 1(12.6), 4–0.
Ahmed, A. S., Khodair, H., Eldahshan, R. M., & Al-Adl, A. S. (2022). Prevalence of Cutaneous Disorders among Diabetic Patients in Damietta Governorate: A Cross Sectional study. International Journal of Medical Arts, 4(2), 2112–2117.
Ahmed, K., Muhammad, Z., & Qayum, I. (2009). Prevalence of cutaneous manifestations of diabetes mellitus. J Ayub Med Coll Abbottabad, 21(2), 76–79.
Al-Mutairi, N., Zaki, A., Sharma, A. K., & Al-Sheltawi, M. (2006). Cutaneous manifestations of diabetes mellitus: Study from Farwaniya Hospital, Kuwait. Medical Principles and Practice, 15(6), 427–430.
Baker, N., & Al-Muzaini, A. (2018). A user’s guide to skin and nail conditions in diabetes. Diabet Foot, 4, 31–39.
Bose, R., & Kumar, S. (2020). Dermatological manifestations in diabetes mellitus. Pain, 21, 17–5.
Butt, N. I., Mahmood, K., Kanwal, N., & Ashfaq, F. (2023). Acanthosis nigricans in patients with type II diabetes mellitus at a tertiary care hospital of Lahore. Journal of Bahria University Medical and Dental College, 13(01), 13–17.
Chang, J. J. (2019). Calciphylaxis: Diagnosis, pathogenesis, and treatment. Advances in Skin & Wound Care, 32(5), 205–215.
Chatterjee, N., Chattopadhyay, C., Sengupta, N., Das, C., Sarma, N., & Pal, S. K. (2014). An observational study of cutaneous manifestations in diabetes mellitus in a tertiary care Hospital of Eastern India. Indian Journal of Endocrinology and Metabolism, 18(2), 217–220.
David, P., Singh, S., & Ankar, R. (2023). A comprehensive overview of skin complications in diabetes and their prevention. Cureus, 15(5). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10259731/
De Macedo, G. M. C., Nunes, S., & Barreto, T. (2016). Skin disorders in diabetes mellitus: An epidemiology and physiopathology review. Diabetology & Metabolic Syndrome, 8(1), 63. https://doi.org/10.1186/s13098-016-0176-y
Duff, M., Demidova, O., Blackburn, S., & Shubrook, J. (2015). Cutaneous manifestations of diabetes mellitus. Clinical Diabetes, 33(1), 40–48.
Gaisne, R., Péré, M., Menoyo, V., Hourmant, M., & Larmet-Burgeot, D. (2020). Calciphylaxis epidemiology, risk factors, treatment and survival among French chronic kidney disease patients: A case-control study. BMC Nephrology, 21(1), 63. https://doi.org/10.1186/s12882-020-01722-y
García-Lozano, J. A., Ocampo-Candiani, J., Martínez-Cabriales, S. A., & Garza-Rodríguez, V. (2018). An Update on Calciphylaxis. American Journal of Clinical Dermatology, 19(4), 599–608. https://doi.org/10.1007/s40257-018-0361-x
George, S. M., & Walton, S. (2014). Diabetic dermopathy. British Journal of Diabetes, 14(3), Article 3. https://doi.org/10.15277/bjdvd.2014.027
Gloster Jr, H. M., Gebauer, L. E., & Mistur, R. L. (2015). Absolute Dermatology Review: Mastering Clinical Conditions on the Dermatology Recertification Exam. Springer.
Grimes, P. E. (2016). Vitiligo: Pathogenesis, clinical features, and diagnosis. En: Tsao H (Editor). UpToDate. https://pearlgrimesmd.com/wp-content/uploads/2023/09/Vitiligo_-Pathogenesis-clinical-features-and-diagnosis-UpToDate.pdf
Henry, D., & Singh, A. (2020). A study of pattern of cutaneous manifestations in patients with diabetes mellitus. Journal of Pakistan Association of Dermatologists, 30(1), 161–166.
Hud, J. A., Cohen, J. B., Wagner, J. M., & Cruz, P. D. (1992). Prevalence and significance of acanthosis nigricans in an adult obese population. Archives of Dermatology, 128(7), 941–944.
Jedlowski, P. M., Te, C. H., Segal, R. J., & Fazel, M. T. (2019). Cutaneous Adverse Effects of Diabetes Mellitus Medications and Medical Devices: A Review. American Journal of Clinical Dermatology, 20(1), 97–114. https://doi.org/10.1007/s40257-018-0400-7
Kawen, A. A., & Al-Waeli, D. K. (2020). Common Skin Disorders Associated with Type 2 Diabetes Mellitusin in Thi-Qar Province, Iraq. European Journal of Molecular & Clinical Medicine, 7(2), 31–37.
Kiprono, S., Minde, E., Mavura, D. R., & Masenga, J. E. (2015). Prevalence of cutaneous manifestations of diabetes mellitus: A hospital-based cross-sectional study in northern Tanzania. East African Medical Journal, 92(5), 221–225.
Korde, S. S., Gugle, A. S., & Pawar, M. K. (2018). A Study of Association of Diabetes Mellitus and Vitiligo Patients. MVP Journal of Medical Sciences, 125–133.
Lee, S. Y., & Sheth, C. A. (2019). Eruptive xanthoma associated with severe hypertriglyceridemia and poorly controlled type 1 diabetes mellitus. Journal of CommunityHospital Internal Medicine Perspectives, 9(4), 344–346. https://doi.org/10.1080/20009666.2019.1650591
Lima, A. L., Illing, T., Schliemann, S., & Elsner, P. (2017). Cutaneous Manifestations of Diabetes Mellitus: A Review. American Journal of Clinical Dermatology, 18(4), 541–553. https://doi.org/10.1007/s40257-017-0275-z
Margossian, M. L., & Sabban, E. N. C. (2018). Cutaneous Manifestations Induced by Antidiabetic Treatment. In E. N. Cohen Sabban, F. M. Puchulu, & K. Cusi (Eds.), Dermatology and Diabetes (pp. 179–197). Springer International Publishing. https://doi.org/10.1007/978-3-319-72475-1_12
Morgan, A. J., & Schwartz, R. A. (2008). Diabetic dermopathy: A subtle sign with grave implications. Journal of the American Academy of Dermatology, 58(3), 447–451.
Pal, R., Bhattacharjee, R., Chatterjee, D., Bhadada, S. K., Bhansali, A., & Dutta, P. (2020). Exogenous insulin-induced localized acanthosis nigricans: A rare injection site complication. Canadian Journal of Diabetes, 44(3), 219–221.
Patel, N. U., Roach, C., Alinia, H., Huang, W., & Feldman, S. (2018). Current treatment options for acanthosis nigricans. Clinical, Cosmetic and Investigational Dermatology, Volume 11, 407–413. https://doi.org/10.2147/CCID.S137527
Penman, I. D., Ralston, S. H., Strachan, M. W., & Hobson, R. (2022). Davidson’s Principles and Practice of Medicine E-Book: Davidson’s Principles and Practice of Medicine E-Book. Elsevier Health Sciences.
Poorana, B., Prasad, P. V. S., Kaviarasan, P. K., Selvamuthukumaran, S., & Kannambal, K. (2019). Impact of Glycaemic Control on the Pattern of Cutaneous Disorders in Diabetes Mellitus-A Hospital Based Case Control Study. Journal of Clinical & Diagnostic Research, 13(2).
Ralston, S. H., Penman, I. D., Strachan, M. W., & Hobson, R. (2018). Davidson’s Principles and Practice of Medicine: Davidson’s Principles and Practice of Medicine E-Book. Elsevier Health Sciences.
Richardson, T., & Kerr, D. (2003). Skin-Related Complications of Insulin Therapy: Epidemiology and Emerging Management Strategies. American Journal of Clinical Dermatology, 4(10), 661–667. https://doi.org/10.2165/00128071-200304100-00001
Romano, G., Moretti, G., Di Benedetto, A., Giofre, C., Di Cesare, E., Russo, G., Califano, L., & Cucinotta, D. (1998). Skin lesions in diabetes mellitus: Prevalence and clinical correlations. Diabetes Research and Clinical Practice, 39(2), 101–106.
Ruderman, I., Toussaint, N. D., Hawley, C. M., Krishnasamy, R., Pedagogos, E., Lioufas, N., & Elder, G. J. (2021). The Australian Calciphylaxis Registry: Reporting clinical features and outcomes of patients with calciphylaxis. Nephrology Dialysis Transplantation, 36(4), 649–656.
Salati, S. A., Alqarawi, L. A., & Alquraishi, Y. F. (2021). Acanthosis nigricans: An extensive review. Journal of Pakistan Association of Dermatologists, 31(2), 273–288.
Sambura, M., Rosolowska-Żak, S., Paluchowska, J., Szymkowicz, A., Paschke, P., & Miczek, I. (2024). Diabetes mellitus and its skin manifestations-dermatology for diabetologists. Journal of Education, Health and Sport, 62, 129–142.
Sanches, M. M., Roda, Â., Pimenta, R., Filipe, P. L., & Freitas, J. P. (2019). Cutaneous manifestations of diabetes mellitus and prediabetes. Acta Medica Portuguesa, 32(6), 459–465.
Sani, H., Abubakar, A. B., & Bakari, A. G. (2020). Prevalence and pattern of skin diseases in patients with diabetes mellitus at a tertiary hospital in Northern Nigeria. Nigerian Journal of Clinical Practice, 23(7), 970–974.
Shahzad, M., Al Robaee, A., Al Shobaili, H. A., Alzolibani, A. A., Al Marshood, A. A., & Al Moteri, B. (2011). Skin manifestations in diabetic patients attending a diabetic clinic in the Qassim region, Saudi Arabia. Medical Principles and Practice, 20(2), 137–141.
Stingeni, L., Tramontana, M., Cordera, L., Castello, M., & Parodi, A. (2021). Xerosis in patients with Type 2 diabetes: An Italian multicentre study. Acta Dermato-Venereologica, 101(10). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9425613/
SY, B. S., Lipoff, J. B., & Chatterjee, K. (2017). Acrochordon. https://europepmc.org/books/nbk448169
Van Hattem, S., Bootsma, A. H., & Thio, H. B. (2008). Skin manifestations of diabetes. Cleve Clin J Med, 75(11), 772–774.
Vâță, D., Stanciu, D.-E., Temelie-Olinici, D., Porumb-Andrese, E., Tarcău, B.-M., Grecu, V.-B., & Gheucă-Solovăstru, L. (2023). Cutaneous Manifestations Associated with Diabetes Mellitus—A Retrospective Study. Diseases, 11(3), 106.
Venkatswami, S., & Anandan, S. (2014). Acanthosis nigricans: A flag for insulin resistance. Journal of Endocrinology, Metabolism and Diabetes of South Africa, 19(2), 68–74.
Zaremba, J., Zaczkiewicz, A., & Placek, W. (2013). Eruptive xanthomas. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 30(6), 399–402.
Al-wesabi M. (2012). The Role of Quality Systems in Improving the Performance of Healthcare Facilities in Yemen: A Case Study of the 48 Model Hospital. https://doi.org/10.13140/RG.2.2.12720.32009
Al-wesabi M. (2017). The Effect of Health Human Resources Development on the Efficacy of Applying Accreditation Standards in Yemeni Hospitals: A Field Study. https://doi.org/10.13140/RG.2.2.28658.67527
Measar, M., & Al-Hoothi, E. (2023). Giant Cerebral Cavernoma: A Case Study. Journal of 21 September University for Medical and Applied Sciences, 2(1). https://doi.org/10.65693/masj.2023.v2i1.21
Abuarij, M., & Al Qtwani, A. (2023). Efficacy of Oral Isotretinoin in Combination with Desloratadine in the Treatment of Acne Vulgaris at Al-Thawrah General Hospital, Sana’a, Yemen . Journal of 21 September University for Medical and Applied Sciences, 2(1), 17-30. https://doi.org/10.65693/masj.2023.v2i1.23
Al-Wesabi, M., & Shamlan, M. (2022). The Effect of Applying Infection Prevention and Control Standards in Sana’a Governorate Hospitals at the Level of Reducing the Spread of Diseases and Epidemics. Journal of 21 September University for Medical and Applied Sciences, 1(1). https://doi.org/10.65693/masj.2022.v1i1.17
2. Alyahawi, A., Al-Wesabi, M., & ALKaf, A. (2022). Antimicrobial susceptibility of Acinetobacter clinical isolates among ICU Patients in Sana’a City, Yemen. Journal of 21 September University for Medical and Applied Sciences, 1(1). https://doi.org/10.65693/masj.2022.v1i1.14
Al-Wesabi, M. (2020). The reality of the Yemeni health sector and the role of September 21 University for Medical and Applied Sciences in reforming it and building the modern Yemeni state (M. Dael, Trans.). Institutional Repository for Scientific Scholarship at 21 September University for Medical and Applied Sciences, 1(1), 106-133. https://doi.org/10.65693/irss.2020.v1i1.47
Abuarij, M., & Al-Agbari, A. (2024). Epidemiological Situation of Mucocutaneous Leishmaniasis in Yemen: A Descriptive Study in the Period from January 2017 to December 2022. Journal of 21 September University for Medical and Applied Sciences, 3(1), 1-11. https://doi.org/10.65693/j21umas.2024.v3i1.200
Alyahawi A, Measar M, Alwesabi M, Alkaf A. (2024). Clinically Significant Statin-Drug Interactions in Older Patients with Chronic Diseases. Pharmaceutical Research - Recent Advances and Trends Vol. 4, B P International, pp.1-21. https://doi.org/10.9734/bpi/prrat/v4/598
Al-Akwa, S., Al-Azizi, J., Al-Nofeesh, M., Jarwash, F., Salem, R., Al-Doais, T., Al-Hajjaji, B., Al-Samei, A., Al-Wesabi, M., Al-Madoumi, I., Abdulmoghani, I., Al-Awadhi, A., Al-Ataki, A., & Al-Nazari, M. (2024). The Role of Governance in Improving the Quality of Healthcare Services in Yemeni Hospitals: (A Case Study of the Republican Teaching Hospital Authority). Institutional Repository for Scientific Scholarship at 21 September University for Medical and Applied Sciences, 5(1), 1-133. https://doi.org/10.65693/irss.2024.v5i1.39
Al-Wesabi, M., & Jarallah. et al, M. (2024). The Reality of Training Quality and its Role in Improving the Performance of Operating Theater Technicians in Yemeni Hospitals: A Comparative Analytical Study Between the Republican Teaching Hospital Authority and Kuwait University Hospital. Institutional Repository for Scientific Scholarship at 21 September University for Medical and Applied Sciences, 5(1), 1-92. https://doi.org/10.65693/irss.2024.v5i1.49
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