The Role of Clinical Pharmacists in the Detection and Evaluation of Adverse Drug Events: A Review Article
DOI:
https://doi.org/10.65693/j21umas.2025.v4i1.220Keywords:
Adverse drug events, Clinical pharmacists, Detection, Evaluation, Role.Abstract
Adverse drug events (ADEs) are a major healthcare systems issue in hospitals. They are difficult to detect because of incomplete or unavailable medication history. Clinical pharmacists have an important role to play in detection and evaluation of adverse drug reactions. The clinical pharmacist's role in medication management should extend beyond simply dispensing drugs, and this article delineates the rationale and proactive approaches for clinical pharmacist detection and assessment of adverse drug reaction (ADRs). This article was designed to overview the role of clinical pharmacists in detecting and evaluating ADRs. Search and analysis of related articles in web sites revealed that clinical pharmacists have an important role in evaluating, identifying, and preventing ADRs, which leads to proper management and decreased number of morbidity and mortality cases. Therefore, healthcare systems need to be redesigned to more fully utilize health information technologies and clinical pharmacists in detecting and responding to ADRs.
References
World Health Organization (2020). Safety monitoring of medicinal product: Guidelines for setting up and running a pharmacovigilance centre. Available at: https://who-umc.org/media/1703/24747.pdf (Accessed April 30, 2022). Lazarou Jet al. Incidence of adverse drug reactions in hospitalized patients. JAMA 1998; 279: 1200-1205. DOI: 10.1001/jama.279.15.1200. Sultana Jet al. Clinical and economic burden of adverse drug reactions. J Pharmacol Pharmacother 2013; 4(Suppl 1): S73-S77. doi: 10.4103/0976-500X.120957. Pirmohamed M, James S, Meakin S, Green C, Scott A, Walley T, et al. Adverse drug reactions as cause of admission to hospital: prospective analysis of 18820 patients. BMJ. 2004;329:15-9. DOI: 10.1136/bmj.329.7456.15. Guignard B, Bonnabry P, Perrier A, Dayer P, Desmeules J, Samer CF. Drug-related problems identification in general internal medicine: The impact and role of the clinical pharmacist and pharmacologist. Eur J Intern Med 2015; 26: 399-406. doi: 10.1016/j.ejim.2015.05.012. Van Grootheest A et al. The role of hospital and community pharmacists in pharmacovigilance. Res Social Adm Pharm 2005; 1: 126-133. doi: 10.1016/j.sapharm.2004.12.009. Kaboli PJ, Hoth AB, McClimon BJ, Schnipper JL. Clinical pharmacists and inpatient medical care: a systematic review. Arch Intern Med. 2006;166:955-64.https://doi.org/10.1001/archinte.166.9.955. American College of Clinical Pharmacy. The role of the pharmacist in the health system: preparing the future care pharmacist. Pharmacotherapy, 2014, 34(8), e133-e146. K. K. Sharma, Arinjay Jain, Shubham Singh Tyagi, Yash Goel, Sebu and Piyush Mittal. Clinical Pharmacist's Role in Medication Error Detection and Management. AJMPCP, 5(4): 11-20, 2022; Article no. AJMPCP.84554. Beninger P. Pharmacovigilance: An Overview. Clin Ther. 2018;40(12):1991-2004. 10.1016/j.clinthera.2018.07.012. Edwards, I. R., & Aronson, J. K. Adverse drug reactions: Definitions, diagnosis, and management. Lancet, 2000, 356(9237), 1255- 1259. https://doi.org/10.1016/S0140-6736(00)02799-9. Schatz S, Weber R. Adverse drug reactions. Pharm Pract. 2015; 1:1. Institute of Medicine Committee on Quality of Health Care in A; Kohn LT, Corrigan JM, Donaldson MS, editors. To Err is Human: Building a Safer Health System. Washington (DC): National Academies Press (US); 2000. Wittich CM, Burkle CM, Lanier WL. Medication errors: An overview for clinicians. Mayo Clin Proc 2014:89:111625. DOI: 10.1016/j.mayocp.2014.05.007. The Pharmaceutical Care Network of Europe. The PCNE Drug related Problems Classification Version 8.01. Available from: https://www.pcne.org/upload/files/215_PCNE_classification_V801.pdf. [Last accessed on 2017 May 05]. Iasella CJ, Johnson HJ, Dunn MA. Adverse drug reactions: Type A (Intrinsic) or type B (Idiosyncratic). Clin Liver Dis 2017; 21:7387. DOI: 10.1016/j.cld.2016.08.005. Bourgeois FT, Shannon MW, Valim C, Mandl KD. Adverse drug events in the outpatient setting: An 11year national analysis. Pharmacoepidemiol Drug Saf 2010; 19:90110. DOI: 10.1002/pds.1984. Fahad Nabi, Mohd Altaf Dar, Abrar Bashir Malik. Guardians of Safety: The Crucial Role of Pharmacists in Reducing Adverse Drug ReactionsJournal of Community Pharmacy Practice ISSN: 2799-1199 Vol: 03, No. 04, June-July 2023. Maqbool M, Fekadu G, Jiang X, Bekele F, Tolossa T, Turi E, Fetensa G, Fanta K. An up to date on clinical prospects and management of osteoarthritis. Annals of Medicine and Surgery. 2021 Dec 1; 72:103077.doi:10.1016/j.amsu.2021.103077. Majeed A, Bashir R, Farooq S, Maqbool M. Preparation, characterization and applications of nanoemulsions: An insight. Journal of Drug Delivery and Therapeutics. 2019 Mar 15; 9(2):520-7. DOI https://doi.org/10.22270/jddt.v9i2.2410. Zehravi M, Maqbool M, Ara I. Healthy lifestyle and dietary approaches to treating polycystic ovary syndrome: a review. Open Health. 2022 May 2; 3(1):60-5. https://doi.org/10.1515/openhe-2022-0008. Kongkaew C, Noyce PR, Ashcroft DM. Hospital admissions associated with adverse drug reactions: a systematic review of prospective observational studies. Ann Pharmacother. 2008; 42:1017-25. https://doi.org/10.1345/aph.1L037. Bond CA, Raehl CL. Adverse drug reactions in United States hospitals. Pharmacotherapy. 2006; 26:601-8. https://doi.org/10.1592/phco.26.5.601. Neubert A, Dormann H, Weiss J, Egger T, Criegee-Rieck M, Rascher W, et al. The impact of unlicensed and offlabel drug use on adverse drug reactions in paediatric patients. Drug Saf. 2004;27:1059-67.https://doi.org/10.2165/00002018-20042713000006. Turner SE, Nunn AJ, Fielding, Choonara IM. Adverse drug reactions to unlicensed and off-label drugs on paediatric wards: a prospective study. Acta Paediatr. 1999:88:965-8. https://doi.org/10.1111/j.1651-2227.1999.tb00191.x. Gill AM, Leach HJ, Hughes J, Barker C, Nunn AJ, Choonara I. Adverse drug reactions in a paediatric intensive care unit. Acta Paediatr. 1995;84:438-41. https://doi.org/10.1111/j.1651-2227.1995.tb13667.x. Ali S, Egunsola O, Al-Dossari DS, Al-Zaagi IA. Adverse drug reaction reporting in a large tertiary hospital in Saudi Arabia: results of an incentive strategy. Ther Adv Drug Saf. 2018:9:585-90. https://doi.org/10.1177/2042098618790209. Lezarou J, Pomeranz BM, Corey PN. Incidence of adverse drug reaction in hospitalized patient: a meta-analysis of prospective studies. JAMA. 1998:279:1200-5. https://doi.org/10.1001/jama.279.15.1200. Pirmohamed M, Breckenridge AM, Kitteringham NR, Park BK. Adverse drug reactions. BMJ. 1998;316:1295-8. https://doi.org/10.1136/bmj.316.7140.1295. Rodrigues MC, Oliveira CD. Drug-drug interactions and adverse drug reactions in polypharmacy among older adults: an integrative review. Rev Lat Am Enfermagem.2016;24. https://doi.org/10.1590/15188345.1316.2800. Schatz S, Weber R. Adverse drug reactions. Pharm Pract. 2015:1:1. Solmaz Hassani, Azadeh Eshraghi, Morteza Taheri, Farzaneh Hematian, Zahra Sahraei. Clinical Role of Pharmacists in Early Detection, Reporting and Prevention of Medication Errors in a Medical Ward. J Pharm Care 2015;3(3-4):54-60. Hossein Khalili, Shadi Farsaei, Haleh Rezaee, Simin Dashti-Khavidaki. Role of clinical pharmacists' interventions in detection and prevention of medication errors in a medical ward. Int J Clin Pharm (2011) 33:281-284. doi: 10.1007/s11096-011-9494-1. Abdullah Hamed Alonazi, Faris Abdullah Khalaf Almutairi, Fahad Abdullah Ajab Alshkarah, Meshari Mohammad Alotaibi, Mohammed Abdulaziz Mohammed Alshibreen and Ibrahim Abdullah Mesfer Aldawsari. the role of pharmacists in patient care and medication management. Journal of Population Therapeutics & Clinical Pharmacology: Vol.29 No.4 (2022): JPTCP (2577-2581). DOI: https://doi.org/10.53555/jptcp.v29i04.5491. Yash Gupta, Neeraj Kumar, Amrita Shukla and Vishal Rai. Assessment of the Role of Pharmacists in Preventing Medication Errors in Hospital Settings. Journal for Research in Applied Sciences and Biotechnology: Volume-2 Issue-2, 2023, PP. 212-218. DOI: https://doi.org/10.55544/jrasb.2.2.30. Dubey A, Pandey M, Yadav S, Tripathi D, Kumari M, Purohit D, Hypolipidemic and haematological effects of ethanolic extract of Tecoma stans linn(bignoniaceae) seeds in alloxan-induced diabetic albino rats. Korean Journal of Physiology and Pharmacology, 2023:27(1),85-90. DOI:10.25463/kjpp.27.1.2023.8. Baniasadi S, Fahimi F. Adverse drug reactions in a pulmonary teaching hospital: Incidence, pattern, seriousness, and preventability. Curr Drug Saf 2011; 6:2306. DOI: 10.2174/157488611798280942. Gholami K, Shalviri G. Factors associated with preventability, predictability, and severity of adverse drug reactions. Ann Pharmacother 1999; 33:23640. DOI: 10.1345/aph.17440. Koochak HE, Babaii A, Pourdast A, Golrokhy R, Rasoolinejad M, Khodaei S, et al. Prevalence of adverse drug reactions to highly active antiretroviral therapy (HAART) among HIV positive patients in Imam Khomeini hospital of Tehran, Iran. Infect Disord Drug Targets 2017; 17:1169. doi: 10.2174/1871526517666170117111350. Kourorian Z, Fattahi F, Pourpak Z, Rasoolinejad M, Gholami K. Adverse drug reactions in an Iranian department of adult infectious diseases. East Mediterr Health J 2009; 15:13517. doi: 10.1002/pds.1793. Mirbaha F, Shalviri G, Yazdizadeh B, Gholami K, Majdzadeh R. Perceived barriers to reporting adverse drug events in hospitals: A qualitative study using theoretical domains framework approach. Implement Sci 2015; 10:110. Mohebbi N, Shalviri G, Salarifar M, Salamzadeh J, Gholami K. Adverse drug reactions induced by cardiovascular drugs in cardiovascular care unit patients. Pharmacoepidemiol Drug Saf 2010; 19:88994. DOI: 10.1002/pds.1916. Mokhtari F, Nikyar Z, Naeini BA, Esfahani AA, Rahmani S. Adverse cutaneous drug reactions: Eight year assessment in hospitalized patients. J Res Med Sci 2014; 19:7205. Pourseyed S, Fattahi F, Pourpak Z, Gholami K, Shariatpanahi SS, Moin A, et al. Adverse drug reactions in patients in an Iranian department of internal medicine. Pharmacoepidemiol Drug Saf 2009; 18:10410. doi: 10.1002/pds.1663. Saheb SharifAskari F, Saheb SharifAskari N, Javadi M, Gholami K. Adverse drug reactions reported to the drug and poison information center of Tehran, Iran. PLOS One 2017;12:e0185450. https://doi.org/10.1371/journal.pone.0185450. Vaseghi G, Abed A, Jafari E, Eslami N, Eshraghi A. Assessment of adverse drug reaction due to cancer chemotherapy in a teaching oncology hospital in Isfahan, central of Iran. Rev Recent Clin Trials 2016; 11:26672. doi: 10.2174/1574887110666150818112648. Mahmathi Karuppannan, Nur Azzrin Nisha Mohamad Rizal, Kok-Thong Wong, Salmiah Mohd. Ali, Kang-Nee Ting and Helen Boardman. Pharmacists' experiences on adverse drug reaction: 10 years later. Front. Pharmacol., 2022. Drugs Outcomes Research and Policies Volume 2022 https://doi.org/10.3389/fphar.2022.9329. Carlqvist, C., Ekstedt, M., & Lehnbom, E. C. Exploring the impact of pharmacistsupported medication reviews in dementia care: experiences of general practitioners and nurses. BMC Geriatrics, 2024; 24(1), 1-10. https://doi.org/10.1186/s12877-024-05124-9. Olea, A., Grochowski, J., Luetkemeyer, A., Robb, V., & Saberi, P. Role of a clinical pharmacist as part of a multidisciplinary care team in the treatment of HCV in patients living with HIV/HCV coinfection. Integrated Pharmacy Research and Practice, 2018; Volume 7, 105-111. https://doi.org/10.2147/iprp.s169282. Saseen, J. J., Ripley, T. L., Bondi, D., Burke, J. M., Cohen, L. J., McBane, S., McConnell, K. J., Sackey, B., Sanoski, C., Simonyan, A., Taylor, J., & Vande Griend, J. P. ACCP Clinical Pharmacist Competencies. Pharmacotherapy, 2017; 37(5),630-636. https://doi.org/10.1002/phar.1923. Peloso, C., Baylatry, M.-T., Elefant, E., Fernandez, C., Joly, A.-C., & Isnard, F. 41st ESCP symposium on clinical pharmacy: personalised and safe therapy. International Journal of Clinical Pharmacy, 2013; 35(5), 866-1019. https://doi.org/10.1007/s11096-013-9801-0.
Abuarij, M., & Al Qtwani, A. (2023). Efficacy of Oral Isotretinoin in Combination with Desloratadine in the Treatment of Acne Vulgaris at Al-Thawrah General Hospital, Sana’a, Yemen . Journal of 21 September University for Medical and Applied Sciences, 2(1), 17-30. https://doi.org/10.65693/masj.2023.v2i1.23
Al-Wesabi, M., & Shamlan, M. (2022). The Effect of Applying Infection Prevention and Control Standards in Sana’a Governorate Hospitals at the Level of Reducing the Spread of Diseases and Epidemics. Journal of 21 September University for Medical and Applied Sciences, 1(1). https://doi.org/10.65693/masj.2022.v1i1.17
Alyahawi, A., Al-Wesabi, M., & ALKaf, A. (2022). Antimicrobial susceptibility of Acinetobacter clinical isolates among ICU Patients in Sana’a City, Yemen. Journal of 21 September University for Medical and Applied Sciences, 1(1). https://doi.org/10.65693/masj.2022.v1i1.14
Alyahawi A, Measar M, Alwesabi M, Alkaf A. (2024). Clinically Significant Statin-Drug Interactions in Older Patients with Chronic Diseases. Pharmaceutical Research - Recent Advances and Trends Vol. 4, B P International, pp.1-21. https://doi.org/10.9734/bpi/prrat/v4/598
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